Completed Theses

2020

• Direct modeling of tumor growth and time to event data**/ Young Statisticians Session 2020
• Operating Characteristics of Surrogate Endpoint Methods for Normally Distributed Data**/ Young Statisticians Session 2020
• Bayesian Continued Process Verification for Biopharmaceuticals**
• Multiple imputation under not-at-random missingness with application in prediction with qPCR data*

2019

• Qualitätsauswertung der Krankenhausversorgung mit Hilfe von Martingal-Methoden für konkurrierende Risiken*
• Circular statistics in a study connecting dentofacial data and wind instrument positioning*
• Modeling of Dose-Exposure Relationships and Model-Based Extrapolation During Early Clinical Development**

2018

• Selection Effects in Bayesian Hierarchical Models**/ Young Statisticians Session 2019
• Sample Size Calculation in Time-to Event Trials with Non-Proportional Hazards Using GESTATE**/ Bernd-Streitberg Award
• Stochastische Survivalmethoden in der Versicherungsmathematik

2016

• Sample Size Reassessment in Equivalence Trials with Binary Data**
• A Causal Analysis of Ventilator-Associated Pneumonia in Intensive Care/ Bernd-Streitberg Award

2015

• Time-dependent Covariates in the Proportional Subdistribution Hazards Modell
• Zur Varianzschätzung des Mantel-Haenszel-Schätzers des Odds Ratios in stratifizierten Studien

2014

• Incidence rates and competing risks in the history of hospital epidemiology
• Nichtparametrische Schätzung einer Übergangswahrscheinlichkeit in einem Nicht-Markov illness-death-Modell mit Hilfe von konkurrierenden Risiken
• Comparison of Different Estimators regarding the Intra-Individual Correlation in Phase I Trials and their Usage for Trial Design**

2013

• The predicitive distribution of the residual variability in the linear model for clinical cross-over rials**/ Bernd Streitberg Award
• Interaktion von Membranpermeabilität und zugrunde liegendem Mortalitätsrisiko bei inzidenten Dialyse Patienten der MPO Studie*

Cooperations with

Academic Partners*    Industry Partners**    International Cooperations***

2020

• Zusammenhang von Schmerz und Funktionalität im prä- und postoperativen Verlauf bei Patienten mit Osteoarthrose und deren Bedeutung für die Sterblichkeit*
• General Independent Censoring in Event-Driven Trials with Staggered Entry*
• Absolute risk prediction for nested exposure case-control sampling
• Landmarking for left-truncated competing risk data with applications to pregnancy outcome registries*/ Young Statisticians Session 2020

2019

• Ein stabilisierter Aalen-Johansen Schätzer bei kleinen intermediären Risikomengen: Theorie und praktische Beispiele
• Martingale simulation methods for the Fine-Gray model
• Economic sampling designs for rare time-dependent exposures in complex event histories
• Comparison of Time-To-First-Event and Recurrent Event Methods in Multiple Sclerosis Trials**/*** Student Award 2020 of the German Association for Medical Informatics, Biometry and Epidemiology

2018

• Evaluating potential post-treatment preditive and prognostic markers with time-to-event data**
• The statistical analysis if the DEcompressive surgery Plus hypoTHermia for Space Occupying Stroke (DEPTH-SOS) trial, with a view towards mortality and safety*
• Joint Models, Landmarking and the Ulm Osteoarthritis Study*

2017

• Multistate Modeling of Clinical Hold in Randomized Clinical Trials**/ Student Award 2017 of the German Association for Medical Informatics, Biometry and Epidemiology
• An Application of BLRM with Covariates for Dose Finding**/ Young Statisticians Session 2018
• Modeling time-dependent effects for competing risks endpoints in allogeneic stem cell transplantation - a piecewise constant approach* 

2016

• Nested Case-Control Designs and Exposure Density Sampling
• Joint Modelling of Overall Survival and Progression-free Survival**/*** Bernd Streitberg Award.
• Joint modelling of left-truncated observational studies: unmeasured 
  baseline covariates as a consequence of delayed study entry/ Bernd Streitberg Award
• Pseudo-Value Regression for the Excess Length-of-Stay and subsequent Quality-of-Life associated with hospital-acquired Infections

2015

• Bayesian decision criteria in clinical development**
• Estimation of pregnancy outcome probabilities in the presence of heavy left-truncation/ "Young Statisticians Session 2015"
• Nelson-Aalen and Aalen-Johansen estimators for randomly left-truncated and right-censored non-Markov multistate models with application to hospital epidemiology/ Student Award 2015 of the German Association for Medical Informatics, Biometry and Epidemiology
• Analysis of time-dynamic oncological data - in the presence of a non-occurring event of interest*/***
• Schätzung altersbedingter Herzkreislaufrisiken basierend auf Routinedaten*
• Evaluation of the impact of a clinical hold in survival studies under different assumptions regarding the true effect**
• Handling missing data using longitudinal or time-to-event techniques - Simulation studies and practical implementation in the Ulm Birth Cohort Study (UBCS)*
• Bayesian Phase II Optimization for Time-To-Event Data Based on Historical Information**
• Nonparametric estimation of cumulative incidence functions in the presence of dependent left-truncation with application to pregnancy outcome data

2014

• Planning of clinical survival studies in the presence of competing risks
• Wild bootstrapping Nelson-Aalen estimates with application in health services research*/ Bernd Streitberg Award
• Sample size calculations for overall survival in oncology trials incorporating a biomarker using multistate models**
• Investigating the performance of EWOC designs compared to 3+3 in early oncology trials based on historical data**
• Confidence intervals for the difference of proportions adjusted for covariates**
• Robustification of state space models*/***

Cooperations with

Academic Partners*    Industry Partners**    International Cooperations***

2018

• Statistical Evaluation of Non-Standard Time-to-Event Outcomes in Biomedical Research: cumulative PhD where one paper has received the Gustav-Adolf-Lienert-Award